When they reach the station, luck turns out to be on their side as they contact the conductor. Once they reach the train yard, they see many crashed trains and hope the one they were following wasn't one of them. Hoping that the infected have been attracted to the smell of strawberries, they're hypothesis is proven wrong and they must fight the Infected off. A group of four Survivors named Samuel, Don, Jon, and Patricia are following a train to the Elkhorn Train Station to be rescued from the infected city. The story starts around early evening, maybe 6 o' clock in Elkhorn, California. The plot is similar to Left 4 Dead and Left 4 Dead 2 following the aftermath of 'The Infection' two weeks after the events of the second game, making it four weeks after the first infection.

Four survivors named Samuel, Don, John, and Patricia must escape California and head to New York, where the military is having cruise ships save carriers.

Four weeks after the first infection from Patient Zero, the United States has done drastic measures to overpower the infection.